The great thing about the “me, IRL” meme is that it can literally be applied to anything – any image, any word, any situation, any song, any video, any person – and the receiver will know instantly one of two things. Either this is an accurate representation of some self-deprecating habit or aspect of the transmitter, or else it is being shared ironically, as this is so completely not representative of the person in real life (or maybe it is?!?!). Ambiguity or ambivalence is a key element to any meme, and as soon as this element is worn away through overexposure or just the shifting trends of fashion the meme stops being a meme, becoming more like the memory of a meme. Memes exist only so long as remain in circulation. Memes are always already dead or dying, and the transmitter/receiver breathes life into it. Memes are zombies, coming alive between two minds and existing on uncertainty.
Addendum: Joel ‘yolo’ McCoy adds the following which I think is bang-on:
@10rdben IF I MAY a meme is more like a ghost than a zombie! Esp since ghost stories are themselves memes and experience similar mutations.
— ?o?? ???o? ???? (@BooDooPerson) November 17, 2012